Title of article
Synthesis of symmetrical C- and pseudo-symmetrical O-linked disaccharide analogs for arabinosyltransferase inhibitory activity in Mycobacterium tuberculosis
Author/Authors
Ashish K. Pathak، نويسنده , , Vibha Pathak، نويسنده , , James R. Riordan، نويسنده , , William J. Suling، نويسنده , , Sudagar S. Gurcha، نويسنده , , Gurdyal S. Besra، نويسنده , , Robert C. Reynolds، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
4527
To page
4530
Abstract
Herein we report the synthesis of symmetrical C-linked and pseudo-symmetrical O-linked disaccharides structurally related to Araf motifs present in the cell wall of MTB. Their activity in a competition-based arabinosyltransferase assay using [14C]-DPA as the glycosyl donor is also presented. In addition, in vitro inhibitory activity for the disaccharides was determined in a colorimetric broth microdilution assay system against MTB H37Ra and Mycobacterium avium.
Keywords
Tuberculosis , Glycosyltransferases , disaccharides , inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798457
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