Title of article
Design and synthesis of novel, conformationally restricted HMG-CoA reductase inhibitors
Author/Authors
Jeffrey A. Pfefferkorn، نويسنده , , Chulho Choi، نويسنده , , Yuntao Song، نويسنده , , Bharat K. Trivedi، نويسنده , , Scott D. Larsen، نويسنده , , Valerie Askew، نويسنده , , Lisa Dillon، نويسنده , , Jeffrey C. Hanselman، نويسنده , , Zhiwu Lin، نويسنده , , Gina Lu، نويسنده , , Andrew Robertson، نويسنده , , Catherine Sekerke، نويسنده , , Bruce Auerbach، نويسنده , , Alexander Pavlovsky، نويسنده , , Melissa S. Harris، نويسنده , , Graeme Bainbridge، نويسنده , , Nicole Caspers، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
4531
To page
4537
Abstract
Using structure-based design, a novel series of conformationally restricted, pyrrole-based inhibitors of HMG-CoA reductase were discovered. Leading analogs demonstrated potent inhibition of cholesterol synthesis in both in vitro and in vivo models and may be useful for the treatment of hypercholesterolemia and related lipid disorders.
Keywords
statin , Hypercholesterolemia , HMG-CoA reductase inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798458
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