Title of article
Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors
Author/Authors
Ronghui Lin، نويسنده , , George Chiu، نويسنده , , Yang Yu، نويسنده , , Peter J. Connolly، نويسنده , , Shengjian Li، نويسنده , , Yanhua Lu، نويسنده , , MARY ADAMS، نويسنده , , Angel R. Fuentes-Pesquera، نويسنده , , Stuart L. Emanuel، نويسنده , , Lee M. Greenberger، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4557
To page
4561
Abstract
Two series of 3,4-disubstituted pyrazole analogues, 3-(benzimidazol-2-yl)-4-[2-(pyridin-3-yl)-vinyl]-pyrazoles (2) and 3-(imidazol-2-yl)-4-[2-(pyridin-3-yl)-vinyl]-pyrazoles (3), were synthesized as novel cyclin-dependent kinase (CDK) inhibitors. Representative compounds showed potent and selective CDK inhibitory activities and inhibited in vitro cellular proliferation in various human tumor cells. The design, synthesis, and preliminary biological evaluation of these pyrazole compounds are reported.
Keywords
cyclin-dependent kinase inhibitor , Pyrazole analogues , anti-tumor agents , Anti-proliferative agents
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798462
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