Title of article
Design of a partial PPARδ agonist
Author/Authors
Ingrid Pettersson ، نويسنده , , S?ren Ebdrup، نويسنده , , Miroslav Havranek، نويسنده , , Pavel Pihera، نويسنده , , Marek Ko??nek، نويسنده , , John P. Mogensen، نويسنده , , Claus B. Jeppesen، نويسنده , , Eva Johansson، نويسنده , , Per Sauerberg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4625
To page
4629
Abstract
Structure based ligand design was used in order to design a partial agonist for the PPARδ receptor. The maximum activation in the transactivation assay was reduced from 87% to 39%. The crystal structure of the ligand binding domain of the PPARδ receptor in complex with compound 2 was determined in order to understand the structural changes which gave rise to the decrease in maximum activation.
Keywords
PPARd , Partial , Docking , design , agonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798474
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