Title of article :
Heterocyclic α-helix mimetics for targeting protein–protein interactions
Author/Authors :
Shannon M. Biros، نويسنده , , Lionel Moisan، نويسنده , , Enrique Mann، نويسنده , , Alexandre Carella، نويسنده , , Dayong Zhai، نويسنده , , John C. Reed، نويسنده , , Julius Rebek Jr.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
The design and synthesis of α-helix peptidomimetics using inverse electron demand Diels–Alder reactions is described. The potency of the resulting pyridazine-based library to disrupt the Bak/Bcl-XL interaction was tested using an in vitro fluorescence polarization assay.
Keywords :
Pyridzaine , Bak/Bcl-XL , Protein–protein interaction , Diels–Alder , ?-helix mimetic
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
