Title of article
Heterocyclic α-helix mimetics for targeting protein–protein interactions
Author/Authors
Shannon M. Biros، نويسنده , , Lionel Moisan، نويسنده , , Enrique Mann، نويسنده , , Alexandre Carella، نويسنده , , Dayong Zhai، نويسنده , , John C. Reed، نويسنده , , Julius Rebek Jr.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4641
To page
4645
Abstract
The design and synthesis of α-helix peptidomimetics using inverse electron demand Diels–Alder reactions is described. The potency of the resulting pyridazine-based library to disrupt the Bak/Bcl-XL interaction was tested using an in vitro fluorescence polarization assay.
Keywords
Pyridzaine , Bak/Bcl-XL , Protein–protein interaction , Diels–Alder , ?-helix mimetic
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798477
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