Title of article
Adenosine phosphonate inhibitors of lipid II: Alanyl tRNA ligase MurM from Streptococcus pneumoniae
Author/Authors
Elena Cressina، نويسنده , , Adrian J. Lloyd، نويسنده , , Gianfranco De Pascale، نويسنده , , David I. Roper، نويسنده , , Christopher G. Dowson، نويسنده , , Timothy D.H. Bugg، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
3
From page
4654
To page
4656
Abstract
Adenosine and 2′-deoxyadenosine phosphonate transition state analogues act as the first inhibitors for the MurMN/FemABX family of tRNA-dependent ligases implicated in high-level penicillin resistance in Gram-positive bacteria.
Keywords
Streptococcus pneumoniae , MurM , inhibitor , Antibacterial , peptidoglycan biosynthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798480
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