Title of article
Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists
Author/Authors
Yukiyoshi Yamazaki، نويسنده , , Kazutoyo Abe، نويسنده , , Tsutomu Toma، نويسنده , , Masahiro Nishikawa، نويسنده , , Hidefumi Ozawa، نويسنده , , Ayumu Okuda، نويسنده , , Takaaki Araki، نويسنده , , Soichi Oda، نويسنده , , Keisuke Inoue، نويسنده , , Kimiyuki Shibuya، نويسنده , , Bart Staels، نويسنده , , Jean-Charles Fruchart، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4689
To page
4693
Abstract
A combination of benzoxazole, phenoxyalkyl side chain, and phenoxybutyric acids was identified as a highly potent and selective human peroxisome proliferator-activated receptor α (PPARα) agonist. The synthesis, structure–activity relationship (SAR) studies, and in vivo activities of the representative compounds are described.
Keywords
design , PPAR?-selective , structure–activity relationship , synthesis , Triglyceride , Lipid abnormalities , HDL-cholesterol , Nuclear receptor , fibrates , PPAR?
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798486
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