Author/Authors :
Junichi Sakaki، نويسنده , , Kazuhide Konishi، نويسنده , , Masashi Kishida، نويسنده , , Hiroki Gunji، نويسنده , , Takanori Kanazawa، نويسنده , , Hidefumi Uchiyama، نويسنده , , Hiroaki Fukaya، نويسنده , , Hironobu Mitani، نويسنده , , Masaaki Kimura، نويسنده ,
Abstract :
Synthesis and structure–activity relationship of RXR antagonists employing a diazepinylbenzoic acid scaffold are described. Of those antagonists, sulfonamide derivatives (6v and 6w) reveal a high antagonistic activity and good pharmacokinetic properties.
