Title of article
Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5-dione-based HDAC inhibitors
Author/Authors
Lynda Loudni، نويسنده , , Joëlle Roche، نويسنده , , Vincent Potiron، نويسنده , , Jonathan Clarhaut، نويسنده , , Christian Bachmann، نويسنده , , Jean-Pierre Gesson، نويسنده , , Isabelle Tranoy-Opalinski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
4819
To page
4823
Abstract
New histone deacetylase inhibitors have been synthesized and evaluated for their activity against non-small lung cancer cell line H661. These compounds have been designed with diversely substituted 1,4-benzodiazepine-2,5-dione moieties as cyclic peptide mimic cap structures, and a hydroxamate side chain. Biological evaluations demonstrated that benzodiazepine-based HDACi bearing an aromatic substituent at the N1 position exhibited promising antiproliferative and HDAC-inhibitory activities.
Keywords
HDAC inhibitors , 4-Benzodiazepine-2 , 5-dione , Histone deacetylase , 1 , Cyclic peptide mimic
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798508
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