Author/Authors :
Zong-ying Liu، نويسنده , , Bo Wang، نويسنده , , Li-xun Zhao، نويسنده , , Yu-huan Li، نويسنده , , Hua-yi Shao، نويسنده , , Hong Yi، نويسنده , , Xue-fu You، نويسنده , , Zhuo-rong Li، نويسنده ,
Abstract :
Three alkoxyalkyl 2-carboxylate ester derivatives related to zanamivir were synthesized. All of the analogs of zanamivir modified at carboxylic moiety with alkoxyalkyl esters 1a–c showed higher activities than ribavirin on influenza A and B virus in the MDCK cells. Oral treatment or intraperitoneal administration of compound 1c showed significantly protective effects in mice infected with influenza A virus with low toxicities.
