Title of article
Synthesis and anti-influenza activities of carboxyl alkoxyalkyl esters of 4-guanidino-Neu5Ac2en (zanamivir)
Author/Authors
Zong-ying Liu، نويسنده , , Bo Wang، نويسنده , , Li-xun Zhao، نويسنده , , Yu-huan Li، نويسنده , , Hua-yi Shao، نويسنده , , Hong Yi، نويسنده , , Xue-fu You، نويسنده , , Zhuo-rong Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
4851
To page
4854
Abstract
Three alkoxyalkyl 2-carboxylate ester derivatives related to zanamivir were synthesized. All of the analogs of zanamivir modified at carboxylic moiety with alkoxyalkyl esters 1a–c showed higher activities than ribavirin on influenza A and B virus in the MDCK cells. Oral treatment or intraperitoneal administration of compound 1c showed significantly protective effects in mice infected with influenza A virus with low toxicities.
Keywords
Alkoxyalkyl ester , Zanamivir , Influenza
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798515
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