Title of article
Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors
Author/Authors
Shoukou Lee، نويسنده , , Chihiro Shinji، نويسنده , , Kiyoshi Ogura، نويسنده , , Motomu Shimizu، نويسنده , , Satoko Maeda، نويسنده , , Mayumi Sato، نويسنده , , Minoru Yoshida، نويسنده , , Yuichi Hashimoto، نويسنده , , Hiroyuki Miyachi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
4895
To page
4900
Abstract
We designed and synthesized hydroxamic acid derivatives bearing a 4-(3-pyridyl)phenyl group as a cap structure, and found that they exhibit potent histone deacetylase (HDAC) inhibitory activity. A representative compound, 17a, showed more potent growth-inhibitory activity against pancreatic cancer cells and greater upregulation of p21WAF1/CIP1 expression than the clinically used HDAC inhibitor suberoylanilide hydroxamic acid (Zolinza™).
Keywords
Hydroxamic acid , Isoindoklinone , pancreatic cancer , HDAC inhibitor , p21 , HDAC
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798524
Link To Document