Author/Authors :
Nicholas C. Ray، نويسنده , , Robin D. Clark، نويسنده , , David E. Clark، نويسنده , , Karen Williams، نويسنده , , H.G. Hickin، نويسنده , , Peter H. Crackett، نويسنده , , Hazel J. Dyke، نويسنده , , Peter M. Lockey، نويسنده , , Melanie Wong، نويسنده , , René Devos، نويسنده , , Anne White، نويسنده , , Joseph K. Belanoff، نويسنده ,
Abstract :
A virtual screening approach comprising a 3-D similarity search based on known GR modulators was used to identify a novel series of non-steroidal glucocorticoid receptor (GR) antagonists. Optimization of the initial hit to provide potent compounds which exhibit good selectivity against other steroidal nuclear hormone receptors is described.
Keywords :
Glucocorticoid , depression , Psychotic , Antagonist
