Title of article
A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials
Author/Authors
Adam R. Renslo، نويسنده , , Andy Atuegbu، نويسنده , , Prudencio Herradura، نويسنده , , Priyadarshini Jaishankar، نويسنده , , Mingzhe Ji، نويسنده , , Karen L. Leach، نويسنده , , Michael D. Huband، نويسنده , , Michael R. Dermyer، نويسنده , , Luping Wu، نويسنده , , J.V.N. Vara Prasad، نويسنده , , Mikhail F. Gordeev، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5036
To page
5040
Abstract
Oxazolidinone analogs bearing substituted piperidine or azetidine C-rings are described. Analogs with a methyl group at the 3-position of the azetidine ring or the 4-position of the piperidine ring exhibited reduced mitochondrial protein synthesis inhibition while retaining good antibacterial potency.
Keywords
Antibacterials , Oxazolidinones , Selectivity , Mitochondrial protein synthesis inhibition , Azetidines , piperidines
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798548
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