Author/Authors :
Brijesh Kumar Srivastava، نويسنده , , Rina Soni، نويسنده , , Jayendra Z. Patel، نويسنده , , Manish Solanki، نويسنده , , Darshan Valani، نويسنده , , Sunil Gupta، نويسنده , , Bhupendra Mishra، نويسنده , , Vijay Takale، نويسنده , , Purvi Pandya، نويسنده , , Mukul R. Jain، نويسنده , , Pankaj R. Patel، نويسنده ,
Abstract :
Design and synthesis of a few novel methylamino piperidinyl substituted oxazolidinones are reported. Their antibacterial activities have been evaluated in a MIC assay against broader panel of both susceptible and resistant Gram-positive strains. (S)-N-{3-[3-Fluoro-4-(methyl-{1-[3-(5-nitrofuran-2-yl)-acryloyl]-piperidin-4-yl}-amino)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 4i has shown comparable antibacterial activity to linezolid and eperezolid in the MIC assay, additionally compound 4i showed good antibacterial activity with an in vitro MIC value of 2–4 μg/mL against linezolid resistant Staphylococcus aureus (linezolid 16 μg/mL).
Keywords :
In vitro MIC assay , N-Methylamino piperidinylaryloxazolidinones , Gram-positive organism , Linezolid resistant staphylococcus aureus
