Title of article :
Synthesis and optimization of novel and selective muscarinic M3 receptor antagonists
Author/Authors :
Naresh Kumar ، نويسنده , , Kirandeep Kaur، نويسنده , , Shelly Aeron، نويسنده , , Sankaranarayanan Dharmarajan، نويسنده , , Arun D.V. Silamkoti، نويسنده , , ANITA MEHTA، نويسنده , , Suman Gupta، نويسنده , , Anita Chugh، نويسنده , , Jang B. Gupta، نويسنده , , Mohammad Salman، نويسنده , , Venkata P. Palle، نويسنده , , Ian A. Cliffe، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
5
From page :
5256
To page :
5260
Abstract :
A series of constrained piperidine analogues were synthesized as novel muscarinic M3 receptor antagonists. Evaluation of these compounds in binding assays revealed that they not only have high affinity for the M3 receptor but also have high selectivity over the M2 receptor.
Keywords :
M3 selective muscarinic antagonists , Azabicyclohexanes
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2007
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
798593
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=798593
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