Author/Authors :
Daniele Andreotti، نويسنده , , Ilaria Bientinesi، نويسنده , , Stefano Biondi، نويسنده , , Daniele Donati، نويسنده , , Isabelle Erbetti، نويسنده , , Sergio Lociuro، نويسنده , , Carla Marchioro، نويسنده , , Alfonso Pozzan، نويسنده , , Emiliangelo Ratti، نويسنده , , Silvia Terreni، نويسنده ,
Abstract :
Synthesis and antibacterial activity of a new class of ketolide antibiotics, exemplified by the prototype GW680788X (1), are described. The structure of (1) has been elucidated by spectroscopic analysis. The good antibacterial activity shown by (1) in comparison with clarithromycin prompted us to consider this compound as a lead molecule for further exploration.
Keywords :
Macrolides , ketolides , Antibacterial , GW680788X
