Title of article
Dual serotonin transporter inhibitor/histamine H3 antagonists: Development of rigidified H3 pharmacophores
Author/Authors
John M. Keith، نويسنده , , Ann J. Barbier، نويسنده , , Sandy J. Wilson، نويسنده , , Kirstin Miller، نويسنده , , Jamin D. Boggs، نويسنده , , Ian C. Fraser، نويسنده , , Curt Mazur، نويسنده , , Timothy W. Lovenberg، نويسنده , , Nicholas I. Carruthers، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
5325
To page
5329
Abstract
A series of tetrahydroisoquinolines acting as dual serotonin transporter inhibitor/histamine H3 antagonists is described. The introduction of polar aromatic spacers as part of the histamine H3 pharmacophore was explored. A convergent synthesis of the final products allowing late stage introduction of the aromatic side chain was developed. In vitro and in vivo data are discussed.
Keywords
tetrahydroisoquinoline , SERT , Histamine H3 , Serotonin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798606
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