Title of article :
Toward novel HIV-1 integrase binding inhibitors: Molecular modeling, synthesis, and biological studies
Author/Authors :
Claudia Mugnaini، نويسنده , , Suvi Rajamaki، نويسنده , , Cristina Tintori، نويسنده , , Federico Corelli، نويسنده , , Silvio Massa، نويسنده , , Myriam Witvrouw، نويسنده , , Zeger Debyser، نويسنده , , Veljko Veljkovic، نويسنده , , Maurizio Botta، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
4
From page :
5370
To page :
5373
Abstract :
The identification of a novel hit compound as integrase binding inhibitor has been accomplished by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with one of the compounds showing an IC50 = 12 μM.
Keywords :
Integrase inhibitors , HIV-1
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2007
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
798616
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=798616
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