Author/Authors :
Dae-Seop Shin، نويسنده , , Jiin Kim، نويسنده , , Dong Cho Han، نويسنده , , Kwang-Hee Son، نويسنده , , Chang Woo Lee، نويسنده , , Hwan-Mook Kim، نويسنده , , Su-Hyung Hong، نويسنده , , Byoung-Mog Kwon، نويسنده ,
Abstract :
A series of cinnamyl compounds related to 2′-hydroxycinnamaldehyde were synthesized and their antitumor effects against human cancer cells evaluated. Hydroxylamine derivative 6 inhibited the growth of human cancer cells and human colon tumor xenograft in nude mice. Its antitumor effects belong to the induction of apoptosis and arresting cell cycle at G2/M phase, which is confirmed by detection of apoptosis markers and cell cycle analysis.
