Author/Authors :
Subharekha Raghavan، نويسنده , , Zhijian Lu، نويسنده , , Teresa Beeson، نويسنده , , Kevin T. Chapman، نويسنده , , William A. Schleif، نويسنده , , David B. Olsen، نويسنده , , Mark Stahlhut، نويسنده , , Carrie A. Rutkowski، نويسنده , , Lori Gabryelski، نويسنده , , Emilio Emini، نويسنده , , James R. Tata، نويسنده ,
Abstract :
A series of HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. The synthesis and biological activity of the compounds are described.
