Title of article
Design, synthesis and biological evaluation of substituted dioxodibenzothiazepines and dibenzocycloheptanes as farnesyltransferase inhibitors
Author/Authors
Pauline Gilleron، نويسنده , , Nicolas Wlodarczyk، نويسنده , , Raymond Houssin، نويسنده , , Amaury Farce، نويسنده , , Guillaume Laconde، نويسنده , , Jean-François Goossens، نويسنده , , Amélie Lemoine، نويسنده , , Nicole Pommery، نويسنده , , Jean-Pierre Hénichart، نويسنده , , Régis Millet، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
5465
To page
5471
Abstract
A new series of FTase inhibitors containing a tricyclic moiety—dioxodibenzothiazepine or dibenzocycloheptane—has been designed and synthesized. Among them, dioxodibenzothiazepine 18d displayed significant inhibitory FTase activity (IC50 = 17.3 nM) and antiproliferative properties.
Keywords
Farnesyltransferase , cancer , Dioxodibenzothiazepine , Dibenzocycloheptane , cytotoxicity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798635
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