Author/Authors :
Nigel Ribeiro، نويسنده , , Helena Tabaka، نويسنده , , Jean Peluso، نويسنده , , Ludivine Fetzer، نويسنده , , Can Nebigil، نويسنده , , Serge Dumont، نويسنده , , Christian D. Muller، نويسنده , , Laurent Désaubry، نويسنده ,
Abstract :
We synthesized 3-O-methylviridicatin 1 and several analogues of this fungal metabolite. We showed that replacement of the methoxy moiety by a thiomethyl enhanced dramatically its ability to inhibit TNF-α secretion. These results strongly suggest that 4-phenyl-3-methylthioquinolinone 3 may provide the basis for the development of new anti-inflammatory agents.
