Title of article :
Design, synthesis and antitubercular activity of diarylmethylnaphthol derivatives
Author/Authors :
Sajal Kumar Das، نويسنده , , Gautam Panda، نويسنده , , Vinita Chaturvedi، نويسنده , , Y.S. Manju، نويسنده , , Anil K. Gaikwad، نويسنده , , Sudhir Sinha، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A new series of diarylmethylnapthyloxy ethylamines were synthesized by aminoalkylation of diarylmethylnaphthols which were obtained by Friedel–Crafts alkylation on 1- and 2-naphthols using diarylcarbinols as the alkylating agents. The title compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H37Rv in vitro and showed MIC in the range of 3.12–25 μg/ml.
Keywords :
Diarylmethylnaphthol derivatives , antitubercular , Fridel-Crafts
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
