Title of article :
On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide–alkyne cycloaddition
Author/Authors :
Victor Gonçalves، نويسنده , , Benoit Gautier، نويسنده , , Anne Regazzetti، نويسنده , , Pascale Coric، نويسنده , , Serge Bouaziz، نويسنده , , Christiane Garbay، نويسنده , , Michel Vidal، نويسنده , , Nicolas Inguimbert، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Cyclic peptides were obtained, on-resin, by the copper (I) catalysed 1,3-dipolar cycloaddition of azides and alkynes. The reaction led exclusively to the formation of the expected cyclomonomeric products which acted as ligands of the Vascular Endothelial Growth Factor receptor 1.
Keywords :
click chemistry , Huisgen reaction , Antagonist , VEGF receptors , Resin supported synthesis , Cyclic peptide
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
