Author/Authors :
Han Na Seo، نويسنده , , Ja Youn Choi، نويسنده , , Yun Jeong Choe، نويسنده , , Yoonjee Kim، نويسنده , , Hyewhon Rhim، نويسنده , , So Ha Lee، نويسنده , , Jungahn Kim، نويسنده , , Dong Jun Joo، نويسنده , , Jae Yeol Lee، نويسنده ,
Abstract :
The intensive SAR study of 3,4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC50 = 41 ± 1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date.
Keywords :
T-type calcium channel , 3 , Kurtoxin , Blocker , 4-Dihydroquinazoline
