Title of article :
Synthesis and identification of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs with dissociated antiprogesterone activities
Author/Authors :
Chunyang Jin، نويسنده , , G. Manikumar، نويسنده , , John A. Kepler، نويسنده , , C. Edgar Cook، نويسنده , , George F. Allan، نويسنده , , Margaret Kiddoe، نويسنده , , Sheela Bhattacharjee، نويسنده , , Olivia Linton، نويسنده , , Scott G. Lundeen، نويسنده , , Zhihua Sui، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A series of novel 11β-aryl-4′,5′-dihydrospiro[estra-4,9-diene-17β,4′-oxazole] analogs have been evaluated for their antagonist hormonal properties using the T47D cell-based alkaline phosphatase assay and the A549 cell-based functional assay. Some of the compounds showed highly potent, and more selective antiprogestational activity against antiglucocorticoid activity than mifepristone (RU 486).
Keywords :
Steroidal spiro-oxazole , progesterone receptor , Selective progesterone receptor modulators , Glucocorticoid receptor , Antagonist
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
