Title of article :
Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan®
Author/Authors :
Albert J. Molinari، نويسنده , , Eugene J. Trybulski، نويسنده , , Jehan Bagli، نويسنده , , Susan Croce، نويسنده , , John Considine، نويسنده , , Jian Qi، نويسنده , , Kadum Ali، نويسنده , , William DeMaio، نويسنده , , Lynne Lihotz، نويسنده , , David Cochran، نويسنده ,
Abstract :
Small molecule agonists and antagonists of the V2-vasopressin receptor have been discovered and have undergone clinical trials. In conjunction with these discovery programs, the synthesis and biological testing of various metabolites associated with these clinical targets were actively pursued. We now report the results of our synthetic efforts and the corresponding biological data generated for several of the metabolites of WAY-151932 and CL-347985 (Lixivaptan®).
Keywords :
Vasopressin , V2-receptor agonist , V2-receptor antagonist , Lixivaptan®
