Title of article
Structure–activity relationship (SAR) investigations of substituted imidazole analogs as TRPV1 antagonists
Author/Authors
Vijay K. Gore، نويسنده , , Vu V. Ma، نويسنده , , Rami Tamir، نويسنده , , Narender R. Gavva، نويسنده , , James J.S. Treanor، نويسنده , , Mark H. Norman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
5825
To page
5830
Abstract
A novel series of 4,5-biarylimidazoles as TRPV1 antagonists were designed based on the previously reported 4,6-disubstituted benzimidazole series. The analogs were evaluated for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells. These studies led to the identification of a highly potent and orally bioavailable TRPV1 antagonist, imidazole 33.
Keywords
VRI , TRPV1 , Vanilloid receptor-1 , Biaryl imidazoles , TRPV1 antagonists
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798704
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