Author/Authors :
Ping Chen، نويسنده , , Charles G. Caldwell، نويسنده , , Robert J. Mathvink، نويسنده , , Barbara Leiting، نويسنده , , Frank Marsilio، نويسنده , , Reshma A. Patel، نويسنده , , Joseph K. Wu، نويسنده , , Huaibing He، نويسنده , , Kathryn A. Lyons، نويسنده , , Nancy A. Thornberry، نويسنده , , Ann E. Weber، نويسنده ,
Abstract :
A series of substituted imidazopiperidine amides has been prepared and evaluated for inhibition of dipeptidyl peptidase IV (DPP-4). Substitution at the 1- and 3-positions produced increased selectivity for DPP-4 relative to DPP-8 and DPP-9. Compounds in this series had IC50 values as low as 5.8 nM for inhibition of DPP-4.
Keywords :
Dipeptidyl peptidase IV inhibitors , Diabetes , Glucagon-like peptide-1 (GLP-1) , incretin hormones , Imidazopiperidine amides
