Author/Authors :
Johann Leban، نويسنده , , Marcel Baierl، نويسنده , , Jan Mies، نويسنده , , Viola Trentinaglia، نويسنده , , Sandra Rath، نويسنده , , Kerstin Kronthaler، نويسنده , , Kristina Wolf، نويسنده , , Astrid Gotschlich، نويسنده , , Markus H.J. Seifert، نويسنده ,
Abstract :
A novel class of NF-κB pathway signaling inhibitors was discovered by virtual screening, medicinal chemistry, and QSAR analysis. An initial set of compounds inhibited NF-κB signaling in a whole cell reporter gene assay in the micro-molar range. Activity was improved step by step by medicinal chemistry to yield nano-molar signaling inhibitors.
Keywords :
NF-?B , nuclear factor ?B , signaling , inhibitor , Anti-viral , anti-inflammatory
