Title of article :
Discovery, synthesis, and structure–activity studies of tetrazole based growth hormone secretagogues
Author/Authors :
Andrés S. Hern?ndez، نويسنده , , Peter T.W. Cheng، نويسنده , , Christa M. Musial، نويسنده , , Stephen G. Swartz، نويسنده , , Rocco J. George، نويسنده , , Gary Grover، نويسنده , , Dorothy Slusarchyk، نويسنده , , R. Krishna Seethala، نويسنده , , Mark Smith، نويسنده , , Kenneth Dickinson، نويسنده , , Leah Giupponi، نويسنده , , Daniel A. Longhi، نويسنده , , Neil Flynn، نويسنده , , Brian J. Murphy، نويسنده , , David A. Gordon، نويسنده , , Scott A. Biller، نويسنده , , Jeffrey A. Robl، نويسنده , , Joseph A. Tino، نويسنده ,
Abstract :
A novel class of Growth Hormone Secretagogues (GHS), based on a tetrazole template, has been discovered. In vitro SAR and in vivo potency within this new class of GHS are described. The tetrazole 9q exhibits good oral bioavailability in rats and dogs as well as efficacy following an oral 10 mg/kg dose in dogs. Solution and solid phase protocols for the synthesis of tetrazole based GHS have been developed.
