Title of article
Design, synthesis, and biological evaluation of triazolopiperazine-based β-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors
Author/Authors
Jennifer E. Kowalchick، نويسنده , , Barbara Leiting، نويسنده , , KellyAnn D. Pryor، نويسنده , , Frank Marsilio، نويسنده , , Joseph K. Wu، نويسنده , , Huaibing He، نويسنده , , Kathryn A. Lyons، نويسنده , , George J. Eiermann، نويسنده , , Aleksandr Petrov، نويسنده , , Giovanna Scapin، نويسنده , , Reshma A. Patel، نويسنده , , Nancy A. Thornberry، نويسنده , , Ann E. Weber، نويسنده , , Dooseop Kim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
5934
To page
5939
Abstract
Various β-amino amides containing triazolopiperazine heterocycles have been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. These compounds display excellent oral bioavailability and good overall pharmacokinetic profiles in preclinical species. Moreover, in vivo efficacy in an oral glucose tolerance test in lean mice is demonstrated.
Keywords
Dipeptidyl peptidase IV , DPP-4 , Dipeptidyl peptidase IV inhibitors , ?-Amino amides , Triazolopiperazine , DPP-4 inhibitors , type 2 diabetes , Triazolopiperazine-based ?-amino amides
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798725
Link To Document