Title of article
Inhibitors of NF-κB derived from thalidomide
Author/Authors
Esperanza J. Carcache de-Blanco، نويسنده , , Bulbul Pandit، نويسنده , , Zhigen Hu، نويسنده , , Jiandong Shi، نويسنده , , James Andrew Lewis، نويسنده , , Pui-Kai Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
6031
To page
6035
Abstract
A series of compounds originally derived from thalidomide were synthesized and evaluated. The most potent compounds in this series, 5HPP-33 and compound 20, inhibited NF-κB activation in HeLa cells. Preliminary study indicated that the mechanism of inhibition of NF-κB activation is through inhibition of its translocation from the cytoplasm to the nucleus.
Keywords
thalidomide , NF-?B , Nuclear translocation , IKK
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798743
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