Title of article :
Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists
Author/Authors :
Dramane I. Lainé، نويسنده , , Haibo Xie، نويسنده , , Noémie Buffet، نويسنده , , James J. Foley، نويسنده , , Peter Buckley، نويسنده , , Edward F. Webb، نويسنده , , Katherine L. Widdowson، نويسنده , , Michael R. Palovich، نويسنده , , Kristen E. Belmonte، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
In the course of our research program to develop novel muscarinic receptor antagonists for the treatment of COPD, new tropane carbamate derivatives were identified as potent anti-muscarinic agents. The synthesis, structure–activity relationships and pharmacological evaluation that led to the identification of compound 5o, are described.
Keywords :
Quaternary , Antagonists , Muscarinic , Salts , ammonium
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
