Title of article
Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes
Author/Authors
Karem Shanab، نويسنده , , Nipawan Pongprom، نويسنده , , Eva Wulz، نويسنده , , Wolfgang Holzer، نويسنده , , Helmut Spreitzer، نويسنده , , Peter Schmidt، نويسنده , , Babette Aicher، نويسنده , , Gilbert Müller، نويسنده , , Eckhard Günther، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
6091
To page
6095
Abstract
Two series of azanaphthoquinone annelated pyrrolo oximes have been synthesized. The antiproliferative activities of 10 compounds were evaluated on at least four different cell lines. One series of pyrrolo derivatives showed high cytotoxic activity. The effects on cell cycle and caspase activity were investigated. Compounds 9a and 9b showed an accumulation of cells in G2/M phase. Substantial and dose-dependent caspase activity was found after treatment of cells with 9a and 9b. This indicates an apoptosis inducing property of these compounds.
Keywords
Anticancer compounds
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798751
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