Title of article :
Novel synthetic ligands for targeted PET imaging and radiotherapy of copper
Author/Authors :
Hyun-Soon Chong، نويسنده , , Santosh Mhaske، نويسنده , , Mai-Lin Liang، نويسنده , , Sankar Bhuniya، نويسنده , , Hyun A. Song، نويسنده , , Martin W. Brechbiel، نويسنده , , Xiankai Sun، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Novel ligands, NBEA, NBPA, NETA, NE3TA, and NE3TA–Bn, were synthesized and evaluated as potential chelators of copper radioisotopes for use in targeted positron emission tomography (PET) imaging or radiation therapy. The new ligands were radiolabeled with 64Cu, and in vitro stability of the radiolabeled complexes was assessed in rat serum. Serum stability results suggest that among the ligands tested, NETA, NE3TA, and NE3TA–Bn form stable complexes with 64Cu.
Keywords :
Cu-64 , Serum stabilityArticle Outline , targeted radiotherapy , PET imaging , Synthetic chelates , Macrocyclic ligands
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
