Author/Authors :
Fabien Chauveau، نويسنده , , Youssef Aissouni، نويسنده , , Jorg Hamm، نويسنده , , Hervé Boutin، نويسنده , , Domenico Libri، نويسنده , , Frédéric Ducongé، نويسنده , , Bertrand Tavitian، نويسنده ,
Abstract :
In vitro selection of 2′-fluoropyrimidine oligonucleotide aptamers was performed against the N-terminal two-domain fragment of mouse VCAM-1. The SELEX procedure enriched the starting pool in a family of homologous sequences. High binding affinity (10 nM) of one member of this family, aptamer 12.11, was demonstrated in a filter binding assay.
