Author/Authors :
B. Podeszwa، نويسنده , , H. Niedbala، نويسنده , , J. Polanski، نويسنده , , R. Musiol، نويسنده , , D. Tabak، نويسنده , , J. Finster، نويسنده , , K. Serafin، نويسنده , , M. Milczarek، نويسنده , , J. Wietrzyk، نويسنده , , S. Boryczka، نويسنده , , W. Mol، نويسنده , , J. Jampilek، نويسنده , , J. Dohnal، نويسنده , , D.S. Kalinowski، نويسنده , , D.R. Richardson، نويسنده ,
Abstract :
The structure–activity relationships of new quinoline based compounds were investigated. Quinoline-5,8-dione and styrylquinoline scaffolds were used for the design of potentially active compounds. The novel analogues had comparable antiproliferative activity to cisplatin when evaluated in a bioassay against the P388 leukemia cell line. However, these compounds appeared far less efficient against SK-N-MC neuroepithelioma cells. Analogues without the 5,8-dione structure but containing the 8-carboxylic acid group were also found to induce antiproliferative activity. Hydrophobicity as measured by HPLC did not correlate with antiproliferative activity.
Keywords :
Antiproliferative activity , Quinoline-5 , 8-diones , Quinolinecarboxylic acid
