Author/Authors :
Klaus Urbahns، نويسنده , , Michael H?rter، نويسنده , , Markus Albers، نويسنده , , Delf Schmidt، نويسنده , , Beatrix Stelte-Ludwig، نويسنده , , Ulf Brüggemeier، نويسنده , , Andrea Vaupel، نويسنده , , J?rg Keldenich، نويسنده , , Klemens Lustig، نويسنده , , Hideki Tsujishita، نويسنده , , Christoph Gerdes، نويسنده ,
Abstract :
Vitronectin receptor (αVβ3) antagonists have been implicated as a possible new treatment of restenosis following balloon angioplasty. In this work we investigate a series of novel arginine mimetic scaffolds leading to new insight of the αVβ3/ligand interaction. Squaric acid amide 10 is a subnanomolar αVβ3 antagonist with improved potency on human smooth muscle cell migration.
Keywords :
restenosis , biphenyl , RGD , Smooth muscle cell , Vitronectin , urea , arginine , Guanidine mimetic , Squaric acid amide , ?v?3
