Title of article :
New 1,2,3,4-tetrahydropyrrolo[3,4-b]indole derivatives as selective CB2 receptor agonists
Author/Authors :
Daniel Pagé، نويسنده , , Hua Yang، نويسنده , , William Brown، نويسنده , , Christopher Walpole، نويسنده , , Manon Fleurent، نويسنده , , Meredith Fyfe، نويسنده , , François Gaudreault، نويسنده , , Stéphane St-Onge، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
The preparation and evaluation of a novel class of CB2 agonists based on a 1,2,3,4-tetrahydropyrrolo[3,4-b]indole moiety are reported. They showed binding affinities up to 4.2 nM toward CB2 with sub-nanomolar EC50 values. They also showed moderate to good (>350-fold) selectivity over the CB1 receptor.
Keywords :
Cannabinoids , 2 , 1 , 3 , CB2 receptor , Agonists , 4-b]indole
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
