Title of article
Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity
Author/Authors
Akihiro Sugawara، نويسنده , , Toshiaki Sunazuka، نويسنده , , Tomoyasu Hirose، نويسنده , , Kenichiro Nagai، نويسنده , , Yukie Yamaguchi، نويسنده , , Hideaki Hanaki، نويسنده , , K. Barry Sharpless، نويسنده , , Satoshi Omura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
6340
To page
6344
Abstract
An erythromycin analogue, 11,12-di-O-iso-butyryl-8,9-anhydroerythromycin A 6,9-hemiketal (1b), was found to be a potential anti-MRSA and anti-VRE agent. The use of copper catalyzed azide–acetylene cycloaddition, and click chemistry, readily provided 10 types of triazole analogues of 1b in good to nearly quantitative yield. Among the library, 5b exhibited activity against MRSA and VRE bacterial strains, representing more than twice the potency of 1b.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798803
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