Title of article :
Aminocarbonylation route to tolvaptan
Author/Authors :
Yasuhiro Torisawa، نويسنده , , Takuya Furuta، نويسنده , , Takao Nishi MD، نويسنده , , Shinji Aki، نويسنده , , Jun-ichi Minamikawa، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
Pd-catalyzed aminocarbonylation between aryl bromide and NH-benzazepinone was effectively carried out to furnish the key intermediate for tolvaptan (up to 85%) in one step.
Keywords :
Vasopressin , Palladium , Carbonylation , Cesium salt , DBU
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
