Title of article
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists
Author/Authors
Clementina Manera، نويسنده , , Maria Grazia Cascio، نويسنده , , Veronica Benetti، نويسنده , , Marco Allarà، نويسنده , , Tiziano Tuccinardi، نويسنده , , Adriano Martinelli، نويسنده , , Giuseppe Saccomanni، نويسنده , , Elisa Vivoli، نويسنده , , Carla Ghelardini، نويسنده , , Vincenzo Di Marzo، نويسنده , , Pier Luigi Ferrarini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
6
From page
6505
To page
6510
Abstract
A series of new 1,8-naphthyridine and quinoline derivatives were synthesized and evaluated for their cannabinoid receptor affinity. In particular, compounds 2, 5, 11, and 13 showed a high CB2 affinity and CB2 versus CB1 selectivity, in agreement with molecular modeling studies. Furthermore, compound 2 also exhibited in vivo antinociceptive effects.
Keywords
Cannabinoid , CB1 receptor , CB2 receptor , 1 , 8-Naphthyridine , Quinoline
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798833
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