Title of article
Synthesis and evaluation of novel pyrazolidinone analogs of PGE2 as EP2 and EP4 receptors agonists
Author/Authors
Zhong Zhao، نويسنده , , Gian Luca Araldi، نويسنده , , Yufang Xiao، نويسنده , , Adulla P. Reddy، نويسنده , , Yihua Liao، نويسنده , , Srinivasa Karra، نويسنده , , Nadia Brugger، نويسنده , , David Fischer، نويسنده , , Elizabeth Palmer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
6572
To page
6575
Abstract
Replacement of the hydroxy cyclopentanone ring in PGE2 with chemically more stable heterocyclic rings and substitution of the unsaturated α-alkenyl chain with a metabolically more stable phenethyl chain led to the development of potent and selective analogs of PGE2. Compound 10f showed the highest potency and selectivity for EP4 the receptor.
Keywords
Prostaglandin , EP2 , EP4 , agonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798846
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