Title of article :
A simple method for the preparation of PEG-6-mercaptopurine for oral administration
Author/Authors :
Marina Zacchigna، نويسنده , , Francesca Cateni، نويسنده , , Gabriella Di Luca، نويسنده , , Sara Drioli، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A new and efficient method for the synthesis of PEG-6-mercaptopurine is described. The key feature of the proposed approach is the protection of the thiol group against metabolic inactivation. Preliminary in vivo and in vitro evaluations of the macromolecular prodrug have been carried out.
Keywords :
polyethylene glycol , CsF–Celite , PEG , 6-Mercaptopurine , 6-MP , prodrug
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
