Title of article :
Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1
Author/Authors :
Thomas J. Woltering، نويسنده , , Geo Adam، نويسنده , , Alexander Alanine، نويسنده , , Jürgen Wichmann، نويسنده , , Frédéric Knoflach، نويسنده , , Vincent Mutel، نويسنده , , Silvia Gatti، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A series of 1,3-dihydrobenzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Attachment of an 8-(2-aryl)-ethynyl-moiety produced compounds inhibiting the binding of [3H]-LY354740 to rat mGluR2 with low nanomolar affinity and consistent functional effect at both mGluR2 and mGluR3.
Keywords :
LY354740 , mGluR2 , 4]diazepin-2-one , 1 , mGluR2/3 antagonists , Non-competitive antagonists , Metabotrophic glutamate receptors
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
