Title of article
Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1
Author/Authors
Thomas J. Woltering، نويسنده , , Geo Adam، نويسنده , , Alexander Alanine، نويسنده , , Jürgen Wichmann، نويسنده , , Frédéric Knoflach، نويسنده , , Vincent Mutel، نويسنده , , Silvia Gatti، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
6811
To page
6815
Abstract
A series of 1,3-dihydrobenzo[b][1,4]diazepin-2-one derivatives was evaluated as non-competitive mGluR2/3 antagonists. Attachment of an 8-(2-aryl)-ethynyl-moiety produced compounds inhibiting the binding of [3H]-LY354740 to rat mGluR2 with low nanomolar affinity and consistent functional effect at both mGluR2 and mGluR3.
Keywords
LY354740 , mGluR2 , 4]diazepin-2-one , 1 , mGluR2/3 antagonists , Non-competitive antagonists , Metabotrophic glutamate receptors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798891
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