Title of article :
Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging
Author/Authors :
Yi Zhang، نويسنده , , Bijoy Kundu، نويسنده , , Karen D. Fairchild، نويسنده , , Landon Locke، نويسنده , , Stuart S. Berr، نويسنده , , Joel Linden، نويسنده , , Dongfeng Pan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
A neutrophil-specific peptide, cinnamoyl-F(D)LF(D)LFK (cFLFLFK), was conjugated consecutively with a polyethylene glycol moiety (3.4 K) and 2,2′,2″,2 -(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) to form cFLFLFK-PEG-DOTA. After 64Cu labeling, Positron Emission Tomography (PET) imaging was successfully able to detect mouse lung inflammation.
Keywords :
Neutrophil antagonist , Peptide tracer , Inflammation imaging , 64Cu
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
