Title of article :
Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents
Author/Authors :
Maria Cristina Silva Lourenço، نويسنده , , Felipe Rodrigues Vicente، نويسنده , , Maria das Graças Muller de Oliveira Henriques، نويسنده , , André Luis Peixoto Candéa، نويسنده , , Raoni Schroeder Borges Gonçalves، نويسنده , , Thais Cristina M. Nogueira، نويسنده , , Marcelle de Lima Ferreira، نويسنده , , Marcus Vin?cius Nora de Souza، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Abstract :
The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. The compounds 2, 3, 7, 8, 11, 12, 15, 16, and 20 exhibited activity between 25 and 100 μg/mL and could be a good start point to find new lead compounds in the fight against multidrug resistant tuberculosis.
Keywords :
tuberculosis , Thiopheneacetamides , antimycobacterial activity
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
