Title of article
Investigation of the terminal P4 domain in a series of d-phenylglycinamide-based factor Xa inhibitors
Author/Authors
Jeffry B. Franciskovich، نويسنده , , John J. Masters، نويسنده , , Wayne W. Weber II، نويسنده , , Valentine J. Klimkowski، نويسنده , , Michael Chouinard، نويسنده , , Philip R. Sipes، نويسنده , , Lea M. Johnson، نويسنده , , David W. Snyder، نويسنده , , Marcia K. Chastain، نويسنده , , Trelia J. Craft، نويسنده , , Richard D. Towner، نويسنده , , Donetta S. Gifford-Moore، نويسنده , , Larry L. Froelich، نويسنده , , Jeffrey K. Smallwood، نويسنده , , Ronald S. Foster، نويسنده , , Gerald F. Smith، نويسنده , , John W. Liebeschuetz، نويسنده , , Christopher W. Murray، نويسنده , , Stephen C. Young، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
6910
To page
6913
Abstract
Several P4 domain derivatives of the general d-phenylglycinamide-based scaffold (2) were synthesized and evaluated for their ability to bind to the serine protease factor Xa. Some of the more potent compounds were evaluated for their anticoagulant effects in vitro. A select subset containing various P1 indole constructs was further evaluated for their pharmacokinetic properties after oral administration to rats.
Keywords
Factor Xa inhibitors , Antithrombotics , d-Phenylgylcinamides
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798911
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