Title of article
Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity
Author/Authors
Zhijian Zhao، نويسنده , , Ronald G. Robinson، نويسنده , , Stanley F. Barnett، نويسنده , , Deborah Defeo-Jones، نويسنده , , Raymond E. Jones، نويسنده , , George D. Hartman، نويسنده , , Hans E. Huber، نويسنده , , Mark E. Duggan، نويسنده , , Craig W. Lindsley، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
49
To page
53
Abstract
This letter describes the development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved aqueous solubility ( 18 mg/mL) that translates into enhanced cell activity and caspase-3 induction.
Keywords
inhibitors , cancer , kinases , Akt
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798918
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